Noscough (Noscapine + Licorice Extract)

Noscough ^® cough syrup contains the active ingredient Noscapine and Liquorice extract, a medicine that has an antitussive (cough-suppressing) effect. Noscough^® is supplied in 100ml bottles and each 5 mL contains 7 mg noscapine and 5 mg licorice extract for oral administration, a bottle is packed in a box with a leaflet.

Noscapine is a phthalate isoquinoline non-narcotic alkaloid derived from the opium poppy Papaver somniferum, a medicine that has an antitussive (cough-suppressing) effect. Noscapine’s antitussive effects appear to be primarily mediated by its sigma receptor agonist activity.

Therapeutic Fields​ of Noscough

Noscough^® indicated for only
treat dry (tickly) coughs. It does not work for relieving productive (chesty) coughs. Noscough^® is suitable for use in adults and children from
the age of three years.

Tickly / Non-Productive Coughs

Dosing

• Adults

Adults and children aged 12 and above 15-20ml (3-4 cups) three to four times a day (TDS or QID).

• Renal Impairment    

Use with caution in severe impairment.

• Hepatic Impairment

Use with caution in severe impairment.

• Pediatrics

Children aged 3 to 6: 5 ml (1 cup), three to four times a day (TDS or QID).

Children aged 6 to 12: 10 ml (2 cups), three to four times a day (TDS or QID).

Administration of Noscough

• Administer with or without food.
• Be sure to leave at least four hours between doses.
• Shake the bottle gently before use.
• Noscough^® comes with a dosage beaker for measuring the correct amount.

Moderate Interactions

Azelastine, Bromperidiol, Eluxadoline, Opioids (mixed agonist/antagonist), Orphenadrine, Oxomemazine, Paraldehyde, Thalidomide.

• For other Interactions, See Update, Noscapine monograph

Pregnancy

Noscough^® should not be used by pregnant women

Breast-Feeding

Noscough^® should not be used by breast-feeding women

Contraindications & Cautions

• Hypersensitivity to noscapine, morphine, or any component of the formulation.
• Convulsive states.
• Diarrhea associated with infection.
• Pregnancy and Breastfeeding.

Warnings and Precautions

• CNS depression: may cause CNS depression, which may impair physical or mental abilities.
• Hypotension: may cause hypotension, use with caution in patients with Hypovolemia, Cardiovascular disease, or drugs that may exaggerate hypotensive effects.
• Opioid agonist toxicities: Noscapine may share the toxic potentials of opioid agonists and precautions of opioid agonist therapy should be observed.
• Respiratory disease: use with caution in patients with pre-existing respiratory compromise, COPD or other obstructive pulmonary disease, and kyphoscoliosis or other skeletal disorder that may alter respiratory function; critical respiratory depression may occur, even at therapeutic dosages.

Side Effects of Noscough

Side effects have rarely been seen in therapeutic doses.

Hypotension, dizziness, drowsiness, headache, constipation, nausea and vomiting.