Methadone Hydrochloride 40 mg

Methadone is a synthetic µ receptor full agonist and NMDA receptor antagonist, with the longest history of use for opioid use disorder treatment. Also, Methadone 40 mg is particularly useful for the management of hard-to-treat pain syndromes. As an illustration, neuropathic pain, and cancer pain require higher and more frequent doses of shorter-acting opioids. So, Methadone is the most prominent of which involves the central nervous system and organs composed of smooth muscle.

PluviaEndo’s Methadone 40 mg is available in two dosage forms:

*Tablet (5, 20, and 40mg): 10 tablets are packed in a blister and 10 blisters are packaged in one box with a leaflet.

*Oral Solution (25mg/5ml): each 250ml bottle is packaged in one box with a leaflet.

Therapeutic Fields​

Patients on Methadone compared to controls

Had 33%

fewer opioid-positive drug tests

Were 4.44

times more likely to stay in treatment

Opioid use disorder, maintenance treatment

Management of pain severe enough to require an opioid analgesic

Opioid withdrawal, short-term medically supervised

Dosing

Based on clinical guidelines for the use of methadone in the treatment of Opioid Addiction, titrate gradually due to patient response and adverse effects.

Administration

PluviaEndo’s Methadone 40 mg is for oral administration only. So, The preparation must not be injected.

Contraindication

Hypersensitivity to methadone or any component of the formulation; significant respiratory depression; acute or severe bronchial asthma; hypercarbia; GI obstruction, including paralytic ileus (known or suspected), increased intracranial pressure.

Warning and Precautions

Use with caution in patients with a history of cardiac conduction abnormalities, adrenal insufficiency, biliary tract dysfunction, delirium tremens, head injury, intracranial lesions, elevated intracranial pressure, hepatic impairment, mental health conditions, morbidly obesity, prostatic hyperplasia and/or urinary stricture, toxic psychosis, renal impairment, respiratory depression, seizure disorders, thyroid dysfunction, elderly patients, cachectic or debilitated, history of substance use disorder. Avoid use in patients with impaired consciousness or coma and abdominal obstruction.

Drug Interactions

Opioid Agonist and antagonists, Cyp3A4 inducers and inhibitors, CNS Depressants

Side Effects

QT prolongation, Hypotension, Respiratory depression, headache, dizziness, sedation, nausea, vomiting, constipation, and sweating.

As a manufacturer, Pluvia Endo can supply you in grades like USP and BP at competitive prices with the best quality material with Unique Molecules & Know-How. Our Portfolio Contains Several Specific APIs & Finished Dosage Form Medications in The Field of Opioid Medications & Nutraceutical Supplements.

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