Mesalazine 500 mg

Mesalazine 500 mg is an effective medication used primarily for the treatment of inflammatory bowel diseases, including ulcerative colitis and Crohn’s disease. As a member of the aminosalicylate class, mesalazine works by reducing inflammation in the intestines, helping to alleviate symptoms and promote healing. Besides, Vonage Pharma (Former Pluvia Endo), as a manufacturer of pharmaceutical APIs and FDFs, produces Mesalazine API for providers.

Indications

Mesalazine is indicated for:

1. Active Ulcerative Colitis: To treat mild to moderate exacerbations.
2. Maintenance of Remission: To prevent the recurrence of ulcerative colitis symptoms.
3. Crohn’s Disease: To manage mild to moderate symptoms and maintain remission.

Dosage and Administration of Mesalazine 500 mg

1. Recommended Dosage: The typical starting dose for adults is 1.5 g to 4 g per day, divided into two or three doses. The specific dosage may vary based on the severity of the condition and the patient’s response to treatment.
2. Administration: Mesalazine is available in various forms, including tablets, granules, and rectal formulations. It is important to follow your healthcare provider’s instructions regarding dosage and form.

Mechanism of Action of Mesalazine 500 mg

Mesalazine acts locally in the gastrointestinal tract. Although researchers do not fully understand the exact mechanism, they believe that it inhibits the production of inflammatory mediators, thereby reducing inflammation and promoting healing of the intestinal lining.

Side Effects

Like all medications, Mesalazine 500 mg can cause side effects. Common side effects include:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, abdominal pain, and constipation.
• Headaches and muscle aches.
• Skin Reactions: Rash or itching.

Serious Side Effects: While rare, serious side effects may occur, including:

• Allergic reactions (e.g., hives, difficulty breathing).
• Kidney problems (monitoring is recommended).
• Blood disorders (e.g., unexplained bleeding or bruising).

If you experience any severe side effects or symptoms that worsen after starting treatment, contact your healthcare provider immediately.

Precautions

1. Pregnancy and Nursing: You should consult your doctor if you are pregnant or breastfeeding because mesalazine can cross the placenta and may be excreted in breast milk.
2. Kidney Function: Healthcare providers advise regular monitoring of kidney function during treatment due to potential risks associated with mesalazine.

Storage of Mesalazine 500 mg

Store mesalazine at room temperature away from moisture and heat. Keep out of reach of children.

Conclusion

Mesalazine 500 mg is a vital medication for managing inflammatory bowel diseases. By reducing inflammation in the intestines, it helps improve symptoms and maintain remission. Always consult with your healthcare provider for personalized advice and treatment plans tailored to your specific condition.